1,3-acetone dicarboxylic acid
Chinese alias: acetone dicarboxylic acid; 3-oxoglutaric acid
English name: 1, 3-acetonedicarboxylic acid
English alias: 3-Oxoglutaric acid
CAS number: 542-05-2
Molecular formula: C5H6O5
Linear molecular formula: HOOCCH2COCH2COOH
Molecular weight: 146.10
Purity: ≥97%
MDL number: MFCD00002711
Beilstein number: 1447081
EC Number: 208-797-9
1, 3-acetone dicarboxylic acidCharacter description
White or light yellow powder
1, 3-acetone dicarboxylic acidPhysical parameter
Melting point :133-135℃
Water soluble and soluble
1, 3-acetone dicarboxylic aciduse
Pharmaceutical intermediate, used for anticholinergic drugs such as atropine and anisodamine.
1, 3-acetone dicarboxylic acidProduction method
It is prepared by deformating acid from citric acid in the presence of concentrated sulfuric acid. In the industrial process, the fuming sulfuric acid is first put into the reaction tank, and the citric acid is added in batches under agitation when it is cooled to below 50℃. The weight ratio is citric acid: fuming sulfuric acid 1:2.34. At the end of feeding, the temperature rises to 40-45 ° C, the heat preservation reaction is 3h, and then the temperature drops below 10 ° C, the normal water is added (the heat preservation is below 40 ° C), and then the cold is about 15 ° C, centrifuge, rinse with ice water, and shake dry the finished product.
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